Tuesday, January 5, 2021

Open letter (email) to Tomislav Mihaljevic, MD, CEO of Cleveland Clinic

 Dear Sir,


I recently read a blog article which unabashedly promoted old misinformation about depression. Unfortunately, Cleveland Clinic appears to be implicated in this. 

The article itself can be seen at:


Author Sherry Christianson makes the statement that, 

“...clinical depression is a set of signs and symptoms that may add up to a chemical imbalance in the brain. This chemical imbalance is thought to be the underlying cause of clinical depression.”

As I believe you would know, the chemical imbalance “theory” of depression was rather officially disavowed, ten years ago. A recent article about the circumstances and implications is:


and the original disavowal (by no less than the editor, at that time, of Psychiatric Times) is at:


Since 2011, there has been voluminous discussion in public media, and increasing controversy about motives for the continued credulity and frequent mentions of this discredited idea — that “depression” (possibly meaning various indeterminate things) is a chemical imbalance that needs to be corrected in many people with drugs or electroshock. 

When I noticed that the website verywellhealth.com maintains a “proud partnership with Cleveland Clinic” it occurred to me that your institution is also promoting, perhaps inadvertently, the old urban legend. 

I would prefer not to believe that. Modern medicine confronts too many cynics these days, when we are fighting a world-wide pandemic, and we need to trust science. 

I would appreciate any clarification about this that you are willing to offer! My intention is only for broader understanding of the truth.

Yours truly,
S. Randolph Kretchmar
The Law Offices of Kretchmar & Cecala, P.C.
Wilmette, IL
847-370-5410 (mobile)

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